Tuesday, 2 May 2023

Facts About the Muscular System.

Facts About the Muscular System.

The muscular system is what allows your body to move. Muscles are necessary for little movements, like smiling, and for big movements, such as running or throwing.

Some muscles you control, like your bicep when you’re lifting something heavy. Other muscles, such as those that help you breathe, move without you thinking at all.

In addition to being responsible for movement, the muscular system is also what keeps your body in whatever position it’s in against the pull of gravity.

1. Muscles are divided into three types: smooth, cardiac, and skeletal

▪️Smooth muscles are the involuntary muscles in your gut, blood vessels, and elsewhere that work without you consciously thinking about making them move.

▪️Cardiac muscles are in your heart.

▪️Skeletal muscles are attached to the bone and help you with everyday activities ranging from sitting and standing to walking, typing, and doing housework.

2. Your body contains more than 639 muscles

These include the muscles you can feel in your arms and legs, as well as muscles deep inside your body, like the one that keeps your heart beating and those that help you digest food. By comparison, your body has 206 skeletal bones.

3. Muscles are made up of special cells called muscle fibers

Their main quality is contractibility, which means the muscles can shorten or lengthen as needed. Almost all movement in your body happens because of muscle contractibility.

4. The largest muscle in the body is the gluteus maximus

It’s the main extensor muscle of the hip, though you may know it as the large muscle in the buttocks. It’s the largest muscle in the body because its main job is to support your trunk and maintain proper posture. The gluteus maximus is the main muscle used to help you walk upstairs.

5. The smallest muscles in the body are in your inner ear

They include the tensor tympani and the stapedius. They connect to your eardrum and hold your inner ear together. The smallest bones in the body are also in your ear.

6. The strongest muscle, based on its size, is the masseter

It’s a muscle in your jaw. It can close your teeth with a force as great as 200 pounds on your molars.

7. Muscles are attached to bones by tendons

Understanding the difference between tendons and ligaments can be confusing. In addition to attaching muscles to bones, tendons can also attach muscles to parts of your body such as your eyeballs. Ligaments connect one bone to another in your joints.

8. Muscles make up about 40 percent of your total body weight

9. The hardest working muscle in the body is the heart

On an average day, it pumps about 2,500 gallons of blood.

10. Some of your busiest muscles are those controlling eye movements

These muscles are constantly making adjustments as you read, watch TV, or look around you. In an hour of reading, your eyes may make as many as 10,000 coordinated movements.

11. Most of the heat produced in your body comes from muscle contraction

Muscle movement counts for almost 85 percent of the total heatTrusted Source produced inside the body. When you’re cold, your muscles contract involuntarily. When you shiver, those are muscles trying to warm your body.

12. The motor cortex on one side of your brain controls muscle movement on the other side of the body

The motor cortex on the right side of your brain controls the muscles on the left side of the body, while the motor cortex on the left side controls the muscles on your right side.

The brain sends movement signals through the spinal cord and out through the peripheral nervous system in your muscles.

The messages from the brain become more complex when there are more muscles involved in an activity, such as shooting a jump shot in basketball.

13. Muscles usually work in pairs

When one shortens, its corresponding muscle lengthens. Think about doing bicep curls. When you curl your arm up so the bicep is shorter, the tricep on the other side of your arm is straightened out.

14. Muscles can’t push.

They can only pull. When you’re pushing a door open, for instance, your muscles are actually pulling your elbow and shoulder against the door.

No matter what you’re doing, you have muscles at work. But to keep them healthy, they need exercise. Even your heart needs a workout to stay strong, which is why aerobic exercise that gets your heart rate up is so important.

The muscles in your arms, legs and elsewhere need exercise, too. As you age, you start to lose muscle mass. But if you exercise your muscles with strength training and resistance exercises, you can slow down that process and maintain a mighty muscular system for a long time. And that’s a fact.


ANTICANCER DRUGS


DRUG OF CHOICE SERIES
ANTICANCER DRUGS

▪️Drug of choice for breast cancer - Tamoxifen

▪️Drug of choice for glioma - Nitrosourea

▪️Drug of choice for colorectal cancer - 5 Fluorouracil

▪️Drug of choice for choriocarcinoma - Methotrexate

▪️Drug of choice for pancreatic carcinoma - Gemcitabine

▪️First line chemotherapy for cervix carcinoma - Cisplatin

▪️Drug of choice for the brain tumor - Lomustine

▪️Drug of choice for prostate carcinoma - Flutamide

▪️Drug of choice for insulinoma - Streptozotocin

▪️Drug of choice for polycythemia vera - Busulphan or Chlorambucil

▪️Drug of choice for carcinoma of endometrium - Progestins

▪️Drug of choice for kaposi sarcome - IF2 alpha

▪️Drug of choice for CLL - Chlorambucil or Fludarabine

▪️Drug of choice for acute myelocytic leukemia - Cytarabine with Mitoxantrone

▪️Drug of choice for wilm's tumor - Vincristine with Danctinomycin

▪️Drug of choice for acute promyeloblastic leukemia - Retinoic acid

▪️Drug of choice for hairy cell leukemia - Cladarabine

▪️Drug of choice for thyroid carcinoma-1-131 with Doxarubicin and cisplatin

▪️Drug of choice for stomach cancer - Fluorouracil with Cisplatin

▪️Drug of choice for CML-Imatinib or Busulfan

▪️Drug of choice for acute lymphocytic leukemia (ALL) - Vincristine +Prednisolone +Mercaptopurine + Cyclophosphamide +Methotrexate

▪️Drug of choice for ovarian cancer - Cisplatin with Paclitaxel

▪️Drug of choice for lung cancer - Cisplatin with Taxane

▪️Drug of choice for malignant melanoma - Dacarbazine

▪️Drug of choice for testicular cancer - Bleomycin+ Etoposide + Cisplatin

Monday, 1 May 2023

HEMATOLOGY

HEMATOLOGY

▪️Drug of choice for mierocytic anemia - Ferrous Sulfate

▪️Drug of choice for iron deficiency anemia in pregnancy - Ferrous sulphate

▪️Drug of choice for warfarin overdose - Vitamin K 

▪️Drug of choice for heparin overdose - Protamine sulphate

▪️Drug of choice for hairy cell leukemia - Cladribine 

▪️Drug of choice for chronic lymphocytic leukemia - Fludarabine

▪️Drug of choice for chronic myeloid leukemia (CML) - Imatinib 

▪️Drug of choice for chemotherapy-induced anemia - Erythropoietin

▪️Drug of choice for anemia due to chronic kidney disease (CKD) - Erythropoietin

▪️drug of choice for autoimmune hemolytic anemia - Prednisolone 

▪️Drug of choice for transient ischemic attack (TIA) - Aspirin

▪️Drug of choice for multiple myeloma - Melphalan 

▪️Drug of choice for heparin-induced thrombocytopenia - Argatroban

▪️Drug of choice for chemotherapy-induced leukopenia - Sargramostim 

▪️Drug of choice for chemotherapy induced thrombocytopenia - Oprelvekin

▪️First line drugs for multiple myeloma - Prednisolone, Prednisolone, Cyclophosphamide

▪️Drug of choice for heparin-induced thrombocytopenia - Argatroban

▪️Drug of choice for bleeding due to heparin - Hirudin 

▪️Drug of choice for warfarin overdose - Vitamin K

▪️Drug of choice for heparin overdose - Protamine 

▪️Thrombolytic agent of choice in acute myocardial infarction - Streptokinase 

▪️Drug of choice for arterial fibrillation induced clotting - Warfarin

▪️Drug of choice for prevention of stroke - Aspirin 

▪️Drug of choice for prevention of deep vein thrombosis - Low molecular weight heparin (LMWH)

▪️Drug of choice for preventing bleeding due to thrombolytic therapy-Epsilion amino capronic acid 

▪️Drug of choice for treatment of deep vein thrombosis - Low molecular weight heparin (LMWH)

▪️Drug of choice for pulmonary embolism - Low molecular weight heparin (LMWH)

▪️Drug of choice for anemia in chronic renal failure - Erythropoietin

Saturday, 29 April 2023

DRUG OF CHOICE SERIES1. CENTRAL NERVOUS SYSTEM

DRUG OF CHOICE SERIES

1. CENTRAL NERVOUS SYSTEM

▪️Drug of choice for generalized absent seizure -Ethosuximide and Sodium valproate

▪️Drug of choice for absence (Petit mal) seizures - Valproate

▪️Drug of choice for absence seizures in children - Ethosuximide

▪️Drug of choice for myoclonic seizures in men - Sodium Valproate

▪️Drug of choice for myoclonic seizures in women - Lamotrigine

▪️Drug of choice for focal seizure - Lamotrigine

▪️Drug of choice for generalized tonic-clonic seizures (GTCS) - Lamotrigine

▪️Drug of choice for tonic-clonic seizures - Sodium Valproate

▪️Drug of choice for infantile seizures - ACTH

▪️Drug of choice for rhinorrohea - Citrizine

▪️Drug of choice for phobias - SSRI's

▪️Drug of choice for reducing preanesthetic anxiety - Lorazepam

▪️Drug of choice for status epilepticus - I.V Lorazepam

▪️Drug of choice for febrile seizures - Diazepam

▪️Drug of choice for partial seizures - Carbamazepine

▪️Drug of choice for attention deficit hyperactivity disorder- Methylphenidate

▪️Drug of choice for Alzheimer's disease - Rivastigmine

▪️Drug of choice for obsessive-compulsive disorder (OCD) - Fluoxetine

▪️Drug of choice for drug-induced parkinsonism - Benzhexol

▪️Drug of choice for parkinsonism - Ropinirole, Pramipexole

▪️Drug of choice for glioma - Nitrosourea

▪️Drug which has pain relief properties without opioid disadvantages - Tramadol

▪️Drug of choice for sedation in patients with severe liver failure - Lorazepam

▪️Drug of choice for maintenance treatment of generalized anxiety disorder-Buspirone

▪️Drug of choice for febrile seizures - Diazepam

▪️Drug of choice for endoscopic and colonscopy - Midazolam

▪️Drug of choice for hypnosis in elderly - Zolpidem

▪️Drug of choice for diabetic neuropathy - Topiramate

▪️Drug of choice for neuropathic pain - Lamotrigine or Topiramate or Gabapentin

▪️Drug of choice for reducing alcohol craving - Naltrexone

▪️Drug for decreasing relapse of alcoholism - Acamprosate (NMDA receptor antagonist) or Naltrexone

▪️Drug of choice for alcohol detoxification - Disulfiram

▪️Drug of choice for smoking cessation - Bupropion

▪️Drug of choice for depression in parkinson disease - SSRI's

▪️Drug of choice for parkinson disease - Levodopa

▪️Drug of choice for psycosis in parkinson disease - Clozapine

▪️Drug of choice for depression - SSRI's

▪️Drug of choice for restless leg syndrome - Ropinirole

▪️Drug of choice for violent behaviour - Haloperidol

▪️Drug of choice for psychotic depression - Loxapine

▪️Drug of choice for neutropenia in felty's syndrome- Lithium

▪️Drug of choice for patients with extra pyramidal symptoms (EPS) - Clozapine

▪️Drug of choice for negative symptoms - Clozapine

▪️Drug of choice for treatment resistant schizophrenia - Clozapine

▪️Drug of choice for elderly with schizophrenia - Clozapine

▪️Drug of choice for peripheral neuropathy - Lamotrigine

▪️Drug of choice for bulimia - SSRI's (Eg: Fluoxetine)

▪️Drug of choice for acute mania - Lithium

▪️Drug of choice for serotonin syndrome - Cyproheptadine

▪️Drug of choice for nocturnal enuresis - Desmopressin

▪️Drug of choice for major depression - SSRI's

▪️Drug of choice for heat stroke - Chlorpromazine

▪️Drug of choice for OCD - SSRI's or Clomipramine

▪️Drug of choice for sleep walking - Carbamazepine

▪️Drug of choice for cluster headache - Lithium

▪️Drug of choice for cyclical vomiting - Lithium

▪️Drug of choice for bipolar mood disorder - Lithium

▪️Drug of choice for cerebral edema - Mannitol

▪️Drug of choice for increased intracranial pressure - Mannitol

▪️Drug of choice for psychomotor seizures - Carbamazepine

▪️Drug of choice for mania - Lithium Carbonate

▪️Drug of choice for Huntington chorea - Tetrabenazine

▪️Drug of choice for Parkinsonism - Ropinirole and Pramipexole

▪️Drug of choice for morning sickness - Hyoscine

▪️Drug of choice for multiple sclerosis - Amitriptyline

▪️Drug of choice for acute attack of migraine - Sumatriptan /Ergotamine Drug of choice for night terrors - Benzodiazepines

▪️Drug of choice for atypical depression - MAO inhibitors

▪️Drug of choice for hydrocephalus - Glycerol or Acetazolamide

▪️Drug of choice for cluster headache - Sumatriptan Treatment of choice for cluster headache - High flow 02

▪️Drug of choice for infantile spasm - ACTH

▪️Drug of choice for Huntington chorea - Tetra benzene

▪️Drug of choice for multiple sclerosis - Interferon B

▪️Drug of choice for pulmonary edema - Morphine

▪️Drug of choice generalized anxiety disorders - Diazepam (Benzodiazepines)

▪️Drug of choice for pain in terminal illness - Morphine

▪️Drug of choice for pain of acute myocardial infarction - Morphine

▪️Drug of choice for chronic cancer pain - Morphine

▪️Drug of choice for borderline personality disorder - Buspirone (5 HT partial agonist)

▪️Drug of choice for neonate with respiratory depression due to use of morphine to control severe labour pain - Naloxone

▪️Drug of choice for sedation in liver failure patients - Lorazepam

▪️Drug of choice for decreasing anxiety in children preoperatively- Antihistaminics

▪️Drug of choice for sedation in patients with porphyrias - Benzodiazepines

▪️Drug of choice for trigeminal neuralgia - Carbamazepine

▪️Drug of choice for status absence - Benzodiazepines

▪️Drug of choice for convulsion in lidocaine treated patients - Diazepam

▪️Drug of choice for tardive dyskinesia - Diazepam

▪️Drug of choice for convulsion in tetanus patients - Diazepam

▪️Drug of choice for delirium caused by ketamine - Diazepam

DRUG OF CHOICE -1

Drug of choice▪️DERMATOLOGY

Drug of choice DERMATOLOGY ▪️Drug of choice for taenia - Topical azoles (Eg: clotriamazole) ▪️Drug of choice for erythrodermic psoriasis ...